Endocrine Abstracts

Background: Hypothyroidism has profound effects on cardiac function, however, the effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with acute exacerbation of heart failure (HF) has not been evaluated yet.Methods: We conducted retrospective cohort analyses of outcomes among 231 consecutive patients with treated hypothyroidism who were admitted to the internal medicine departments of Shamir Medical Center with HF...

Aim: The aim of this study was to compare maternal and neonatal outcomes between Israeli Arab and Jewish women with GDM not controlled with lifestyle modification.Methods: We conducted a retrospective cohort study of women with GDM who were not controlled with lifestyle modification and were followed and gave birth in a university affiliated medical center between 2005 and 2015.Results: The study included 343 women, 45 (11.8%) of t...

Background: Previous studies evaluating the association between falling insulin requirements (FIR) during late pregnancy and adverse maternal and neonatal outcomes yielded controversial results.Methods: We conducted a retrospective cohort analysis of data collected from women delivering at Shamir Medical Center (a referral university-affiliated facility in central Israel), between 2008–2018. The percent of FIR was calculated by dividing the remaind...

Background: The diagnosis of hypocortisolism is challenging in hemodialysis (HD) patients due to shared clinical features between renal failure and cortisol deficiency. We hypothesize that in a significant percentage of HD patients we miss cortisol deficiency.Methods: A prospective cohort of 56 end stage kidney disease patients on maintenance HD treatment (mean age 65.3±13.1, females 80 %) was studied. Low dose (1 mg) adrenocorticotropic hormone (AC...

Aim: Loss of protective sensation (LOPS) commonly precede Diabetic foot ulcer (DFU) which is one of the most fearsome/serious diabetic complications and the leading cause of foot amputation in T2D patients. However, the prevalence of this high risk state is unknown.Methods: To estimate the presence of LOPS among hospitalized diabetes patients in internal wards, vibration perception and 10-g monofilament tests were done. Patients with foot ulcer or status...

Background: The management of relapsing Graves’ disease is controversial. Previous surveys from different regions in the world demonstrated variations in the clinical practices of patients with Graves’ disease relapse.Methods: To determine management pattern among endocrinologists in Israel an electronic questionnaire was e-mailed to all members of the Israeli Endocrine Society. Questionnaires included demographic data and clinical scenarios wi...

Introduction: Ovarian adrenal rest tumors (OARTs), in contrast with testicular adrenal rest tumors, are very rare. Up to date, 13 cases were reported in the literature; all treated surgically.Aim: We describe a case of a young female with uncontrolled classical congenital adrenal hyperplasia (CCAH), presenting with bilateral OARTs, successfully treated with steroid replacement.Methods: Data on clinical history and biochemical work-...

Background: Basal-Bolus (BB) insulin treatment is increasingly used in uncontrolled diabetes patients during hospitalization and is commonly recommended on their discharge. However, the extent of adherence with this recommendation is unknown.Aim: To determine the short term adherence of type 2 diabetes mellitus (T2DM) patients discharged from internal medicine wards with recommendation for BB insulin treatment.Methods: Prescription...

Aim: The aim of this study was to evaluate the effect of pre-gestational body mass index (BMI) and gestational weight gain (GWG) on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) controlled with medication.Methods: We conducted a retrospective cohort study of women with singleton pregnancies, diagnosed with GDM and treated with glucose lowering agents that were followed and gave birth between 2005–2015 in the Assaf Haro...

Introduction: GEP-NETs incidence increased markedly over the past decades probably due to increased imaging. GEP-NETs are generally indolent but often have unpredictable biological behavior and aggressive clinical course.Aims: To collect information regarding demographics, presentation, pathology characteristics, treatment and outcome of GEP-NETs.Methods: Following approval of our institutional ethical board, pathology and clinical...